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This medicine is contraindicated: Hypersensitivity to the active substance or to any of the excipients; In children less than 12 years of age; In patients with acute dysentery, which is characterised by blood in stools and high fever; In patients with acute ulcerative colitis; In patients with bacterial enterocolitis caused by invasive organisms including Salmonella, Shigella and Campylobacter; In patients with pseudomembranous colitis associated with the use of broad-spectrum antibiotics.
Loperamide must not be used when inhibition of peristalsis is to be avoided due to the possible risk of significant sequelae including ileus, megacolon and toxic megacolon. Loperamide must be discontinued promptly when ileus, constipation or abdominal distension develop.
